Table 3. Univariable comparison of RCC characteristics between cases (IBD patients who developed RCC) and controls (RCC patients in the general population derived from ECR) (case control study B).
| Variable | IBD and RCC cases (n = 180) | ECR (n = 4388) | Missing values(cases/ECR) | P-value |
|---|---|---|---|---|
| Male gender, n (%) | 114 (63.3) | 2659 (60.6) | 0 | 0.461 |
| Age at RCC diagnosis (y), median | 62 (27–83) | 66 | 0 | <0.001 |
|
Location Left-sided, n (%) Right-sided, n (%) |
89 (50.6) 87 (49.4) |
2119 (48.7) 2230 (51.3) |
4/39 |
0.631 |
|
Grade 1–2, n (%) 3–4, n (%) |
88 (72.7) 33 (27.3) |
1214 (69.3) 539 (30.7) |
59/2635 |
0.442 |
|
T stage T1–T2, n (%) T3–T4, n (%) |
130 (76.9) 39 (23.1) |
2509 (70.9) 1032 (29.1) |
11/847 |
0.089 |
|
N stage N0, n (%) N+, n (%) |
160 (94.1) 10 (5.9) |
3281 (88.6) 423 (11.4) |
10/684 |
0.025 |
|
M stage M0, n (%) M1, n (%) |
155 (87.1) 23 (12.9) |
2962 (80.0) 742 (20.0) |
2/684 |
0.020 |
| Surgery, n (%) | 168 (93.9) | 3318 (75.6) | 1/0 | <0.001 |
| Calendar year of RCC diagnosis, median | 2003 | 2007 | 0 | <0.001 |
RCC, renal cell carcinoma; IBD, inflammatory bowel disease; ECR, Eindhoven cancer registry.