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. 2015 Sep 27;6(34):35522–35541. doi: 10.18632/oncotarget.5849

Figure 2. KAI1/CD82 suppresses the activity of Src via its upstream activator.

Figure 2

KAI1/CD82 plays an important role in cancer metastasis and was initially identified as a metastasis suppressor. KAI1/CD82 could attenuate EGFR signaling by promoting internalization of the activated receptor. It also reduces both integrin-dependent and HGF-induced activation of c-Met, subsequently inhibiting signaling to activate Src, resulting in reduced activation of p130Cas. Moreover, CDCP1, which promotes metastasis via enhancement of Src activity, was found to be suppressed by KAI1/CD82.