Skip to main content
. 2015 Sep 27;6(34):35522–35541. doi: 10.18632/oncotarget.5849

Figure 4. Src increases Rac1 activity by phosphorylating RhoGDI2.

Figure 4

RhoGDI2 binds to Rho GTPases, sequestering them in the cytosol, which subsequently inhibits the activation of the Rho proteins and prevents their interaction with effectors or other regulatory proteins such as GAPs and GEFs. Src activation can modulate the RhoGDI2-Rho GTPase complex formation by phosphorylating RhoGDI2 at Tyr153, which could free Rac1 from its association with RhoGDI2. Subsequently, Rac1 then goes back into a functional cycle between GDP-bound Rac1 or GTP-bound Rac1.