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. 2015 Oct 2;6(34):35667–35683. doi: 10.18632/oncotarget.5523

Figure 8. Schematic summary of the effects of ABT-737 on human oral cancer cells.

Figure 8

The Bim expression levels were significantly increased in response to ABT-737 treatment in MC-3 human mucoepidermoid carcinoma cells, whereas Bim phosphorylation by ERK1/2 on serine 69 promotes its ubiquitination and subsequent proteasomal degradation in HN22 human oral squamous carcinoma cells. The inactivation of the ERK1/2 signaling pathway by ABT-737 treatment reduces the Bim expression levels via both transcriptional and posttranslational regulation in a cell type-dependent manner, inducing mitochondria-mediated apoptosis of human oral cancer cells.