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. 2015 Sep 30;6(34):35797–35812. doi: 10.18632/oncotarget.5929

Figure 5. In vivo pharmacokinetic properties of V158411.

Figure 5

A. Summary of V158411 pharmacokinetics in the mouse, rat and dog following 10 mg/kg IV administration. Mouse data is from a composite profile with 3 mice per time point, rat and dog data are the mean of individual pharmacokinetic profiles (n = 3 or 4). B. Summary of V158411 and irinotecan pharmacokinetics in the mouse following single administration (I) of 30 mg/kg IV V158411 or 100 mg/kg IP irinotecan, or combination administration (C) of 100 mg/kg IP irinotecan followed 2 hours later by 30 mg/kg IV V158411. Data is from composite profiles with 3 mice per time point. C. Pharmacokinetics of V158411 in HT29 tumor bearing mice following 30 mg/kg IV administration in plasma and tumor. Points, mean for three mice per time point; bars, SD. Drug concentrations were determined as detailed in Materials and Methods.