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. 2015 Sep 30;6(34):35797–35812. doi: 10.18632/oncotarget.5929

Figure 6. V158411 potentiates irinotecan cytotoxicity in human tumor xenografts.

Figure 6

A. The MTD dose of V158411 as a single agent (left) or in combination with MTD irinotecan (right) was determined in female nu/nu mice. V158411 was administered IV q7d for 3 weeks as a single agent or 2 hours after 100 mg/kg IP (MTD) irinotecan. Values are the mean normalized body weight of five animals. B. nu/nu mice bearing established Colo205 xenografts were treated q7d for 3 cycles with vehicle, 75 mg/kg IP irinotecan, 60 mg/kg IV V158411 or the combination of 75 mg/kg irinotecan IP followed by 30 mg/kg or 60 mg/kg V158411 IV 2 hours later. Tumor size and body weight were determined as described in the materials and methods. C. Summary of in vivo responses to irinotecan plus V158411 combination therapy.