Figure 7. DHT inhibits resveratrol-induced pro-apoptotic gene expression.
A. MDA-MB-231 cells B. MCF-7 cells were treated with 10 μM resveratrol in the presence or absence of 10−9 M DHT for 24 h. Cells were harvested and total RNA was extracted for QPCR as described in the Materials and Methods section. DHT inhibited the RV-induced gene expressions of CASP2, p53 and COX-2. The resveratrol-suppressed gene expressions of PCNA, HIF-1α and β-catenin were enhanced by DHT. N = 4. *p < 0.05; **p < 0.005; ***p < 0.001, compared to control. # p < 0.05; ## p < 0.01; ### p < 0.001, compared between resveratrol-treated samples in the presence and absence of DHT.