Table 2. MicroRNA altered by radiation exposure in mice progeny spermatozoa as detected by microarray and volcano-plot analyses.
| microRNA | Fold variation (Exposed/Control) | Biological function |
|---|---|---|
| miR-29c* | 0.47 ↓ | role in spermatogenesis; induce apoptosis through increasing Bax/Bcl-2 ratio |
| miR-30c | 2.63 ↑ | regulate myogenic differentiation |
| miR-30e | 2.34 ↑ | induce apoptosis |
| miR34c* | 2.00 ↑ | role in spermatogenesis |
| miR-92a | 0.48 ↑ | prevent endothelial dysfunction in mice |
| miR-98 | 2.29 ↑ | involved in rat embryo implantation; inhibit cell proliferation |
| miR-99b | 2.08 ↑ | promote apoptosis |
| miR-122* | 2.24 ↑ | role in spermatogenesis |
| miR-124 | 3.33 ↑ | tumour suppressor; regulate glucocorticoid sensitivity |
| miR-135a* | 2.04 ↑ | role in spermatogenesis |
| miR-144 | 0.41 ↓ | targets PTEN |
| miR-145 | 2.01 ↑ | tumour suppressor |
| miR-147 | 2.43 ↑ | regulate murine macrophage inflammatory responses |
| miR-181a | 0.46 ↓ | promote osteoclast survival |
| miR-183 | 3.45 ↑ | promote cell proliferation |
| miR-196a | 2.14 ↑ | oncomir |
| miR-326 | 0.45 ↓ | tumour suppressor; regulate dopamine receptor D2 expression |
| miR-338 | 0.48 ↓ | regulate osteogenic differentiation in mice |
| miR-341 | 0.45 ↓ | involved in early development of mice |
| miR-346 | 2.02 ↑ | involved in immune response |
| miR-361 | 2.04 ↑ | tumour suppressor |
| miR-363 | 2.42 ↑ | regulate endothelial cell properties and their communication with hematopoietic precursor cells |
| miR-425 | 3.03 ↑ | regulate production of atrial natriuretic peptide |
| miR-433 | 2.83 ↑ | inhibit cell migration and proliferation |
| miR-449c* | 2.01 ↑ | role in spermatogenesis |
| miR-450a | 2.63 ↑ | Not available |
| miR-465a | 2.46 ↑ | involved in ovarian development, folliculogenesis and female fertility |
| miR-466a | 0.45 ↓ | role in osmoregulation through Nfat5 |
| miR-466f | 0.33 ↓ | role in osmoregulation through Nfat5; pro-apoptotic role |
| miR-466 h | 0.34 ↓ | “ |
| miR-466i | 0.36 ↓ | “ |
| miR-466q | 0.36 ↓ | “ |
| miR-471 | 0.49 ↓ | Not available |
| miR-500 | 2.12 ↑ | liver development |
| miR-503 | 2.33 ↑ | regulate osteoclastogenesis by targeting RANK |
| miR-532 | 0.40 ↓ | pro-apoptotic role |
| miR-666 | 0.44 ↓ | mediate osmolar changes via aquaporin-1 |
| miR-669d | 0.48 ↓ | epigenetic regulators of renal Nfat5 signaling |
| miR-669f | 0.34 ↓ | involved in helper T cell hyper-proliferation |
| miR-669g | 2.18 ↑ | Not available |
| miR-701 | 2.16 ↑ | Not available |
| miR-713 | 2.12 ↑ | Not available |
| miR-714 | 2.05 ↑ | Not available |
| miR-762 | 2.24 ↑ | involved in immune response |
*
miRNA involved in spermatogenesis
↑
upregulated
↓
downregulated