Table 1. Changes in MDM2 and MDMX expression clustered by changes in E-cadherin expression in paired CaP and BrCa samples and respective LN metastases.
| CaP – LN pairs | ↓ E-cadherin in metastasis # of pairs | ↑ E-cadherin in metastasis # of pairs | Total # of pairs |
|---|---|---|---|
| Total | 3 | 13 | 16 |
| ↑ MDM2 in metastasis | 1 | 7 | 8 |
| ↓ MDM2 in metastasis | 1 | 4 | 5 |
| → MDM2 in metastasis | 1 | 2 | 3 |
| ↑ MDMX in metastasis | 0 | 0 | 0 |
| ↓ MDMX in metastasis | 3 | 12 * | 15 |
| → MDMX in metastasis | 0 | 1 | 1 |
| BrCa - LN pairs | |||
| Total | 9 | 9 | 18 |
| ↑ MDM2 in metastasis | 3 | 3 | 6 |
| ↓ MDM2 in metastasis | 3 | 2 | 5 |
| → MDM2 in metastasis | 3 | 4 | 7 |
| ↑ MDMX in metastasis | 6 | 1 | 7 |
| ↓ MDMX in metastasis | 3 | 5 | 8 |
| → MDMX in metastasis | 0 | 3 | 3 |
The table summarizes numbers of cases in specified categories; *, P < 0.0005 by Cochran's Q test. Cases in grey boxes correlate with in vitro observations