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. 2015 Sep 26;6(34):36319–36337. doi: 10.18632/oncotarget.5415

Figure 8. PPARβ/δ-dependent attenuation of MMP2-mediated invasion and migration of NT2/D1 cells.

Figure 8

A. Left panel, activities of MMP2 and MMP9 in NT2/D1-MigR1 (MigR1) and NT2/D1-hPPARβ/δ (hPPARβ/δ) cells treated with vehicle control (C) GW0742 (GW), and/or GSK3787 (GSK). Right panel, relative activity of pro-MMP2. B, C. Real-time invasion or migration of MigR1 and hPPARβ/δ cells in response to SB-3CT. D. Left panel, representative photomicrographs of wound-healing migration assay in MigR1 and hPPARβ/δ cells in response to SB-3CT treatment and, right panel, the average percentage of wound closure after 48 h. Values represent the mean ± S.E.M. Values with different superscript letters are significantly different at p ≤ 0.05. *Significantly different than control, p ≤ 0.05.