Table 1. Genetic and clinical features of the human tumors samples.
Patients | Histological data | Genetic analyses | Relevant clinical data | ||
---|---|---|---|---|---|
BRAF | TP53 | TERT | |||
4 | Papillary, pT3N1b | WT | WT | nd | WDTC, persistent disease, lung metasstasis |
5 | Papillary, pT1Nx | p.V600E | WT | nd | WDTC, cured |
6 | Papillary, pT3N0 | p.V600E | WT | WT | WDTC, cured |
7 | PDTC, pT4aN1 | WT | WT | nd | External radiotherapy, surgery for endotracheal recurrence, persistent disease |
8 | PDTC, pT3N1 | p.V600E | WT | p.C228T | Biochemical persistence |
9 | PDTC, pT3N1b | WT | c.920-2A>G | WT | Resistant to tyrosine-kinase inhibitor, disease-related death at 26 years |
10 | PDTC, pT4aN1b | p.V600E | WT | WT | Persistent disease, local recurrence |
11 | PDTC, pT4aNx | WT | WT | WT | Persistent disease, lost at follow-up |
12 | PDTC, pT4aN1b | WT | WT | nd | Local recurrence, disease-related death at 77 years |
The table summarize the histological, genetic and clinical data of patients with thyroid malignancies.
WDTC, well differentiated thyroid cancer; PDTC, poorly differentiated thyroid cancer; nd, not done.