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. 2015 Oct 22;6(34):36400–36417. doi: 10.18632/oncotarget.5063

Figure 8. Abrogation of MOC1 tumor growth inhibition following mTOR inhibition with systemic CD8 cell depletion.

Figure 8

A. MOC1 cells were transplanted and allowed to form tumors with a volume of 0.1 cm3. Depletion of CD8 cells with 200 μg anti-CD8 antibody IP twice weekly was started one day before initiation of mTOR inhibition with rapamycin. Injection of a non-specific isotype antibody served as control. B. At the completion of the experiment, spleen and tumor tissues were harvest and flow cytometry performed to validate the depletion of CD8 cells both peripherally and in the tumor. Representative dot plots of spleen (top panels) and tumor tissue (bottom panels) are shown.