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. 2015 Sep 15;6(34):36789–36814. doi: 10.18632/oncotarget.5103

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Copyright: © 2015 Chaudhary et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Nuclear localization of p50 and Bcl3 complex and its transcriptional activation drives overexpression of downstream target genes such as Cyclin D1 and N-cadherin. Moreover, activation of both Shh and p50/Bcl3 signaling pathways in basal keratinocytes drive pathogenesis of BCCs in the murine model of NBCCS and in patients with NBCCS. Inhibition of these two pathways together abrogates BCC development in Ptch1^+/−/SKH-1 mice.