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. 2015 Sep 15;6(34):36789–36814. doi: 10.18632/oncotarget.5103

Figure 9. Blocking NFκB and Shh signaling respectively with sulfasalazine (SSZ) and cyclopamine (CYC) reduces growth of BCCs in Ptch1+/−/SKH-1 mice.

Figure 9

A. Effects of SSZ and CYC alone and in combination on UVB-induced BCCs. Effects of these treatments on the number (B) and size of microscopic BCCs (C). D. Relative expression of cyclin D1/2 and their partner kinases CDK4/6 in various treatment groups. E. mRNA expression of Shh signaling-related genes in various treatment groups as described in A. F. Representative photograph showing microscopic BCCs in various treatment groups (blue staining) represents β-gal staining); G. representative images of Bcl3 / N-cadherin / Cyclin D1 immunofluorescence staining in various treatments.