Figure 5. Impact of neoRT and ST timing on lung metastases in NOD/SCID mice.
Tumors implanted into NOD/SCID mice were resected at day 4 (D4) or at day11 (D11) after normofractionated RT (5x2Gy) or hypofractionated RT (2X5Gy). Control NOD/SCID mice (ctrl) did not received neoRT prior to surgery (n = 4-9). A. Average number of global lung metastases. B. Stratification of lung metastasis number according to the size of metastatic foci (< 10 cells; 10 to 50 cells; 50 to 100 cells and >100 cells). C. Tumor volume at the time of tumor resection. Results are expressed as mean + SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ns = non statistically significant.