Table 3. Summary of common AEs with an incidence of ≥ 1% for all grades.
| Adverse events | All grades n (%) | Grade 2 n (%) | Grades 3–4 n (%) |
|---|---|---|---|
| Hand-foot skin reaction | 155 (60.5) | 65 (25.4) | 21 (8.2) |
| Alopecia | 87 (34.0) | 20 (7.8) | 0 (0.0) |
| Rash | 63 (24.6) | 25 (9.8) | 3 (1.2) |
| Diarrhea | 99 (38.7) | 51 (19.9) | 9 (3.5) |
| Constipation | 33 (12.9) | 7 (2.7) | 0 (0.0) |
| Nausea | 49 (19.1) | 17 (6.6) | 1 (0.4) |
| Vomiting | 19 (7.4) | 5 (2.0) | 1 (0.4) |
| Hypertension | 55 (21.5) | 23 (9.0) | 2 (0.8) |
| Angina pectoris and myocardial infarction | 3 (1.2) | 2 (0.8) | 1 (0.4) |
| Anemia | 41 (16.0) | 17 (6.6) | 4 (1.6) |
| Leukopenia | 7 (2.7) | 1 (0.4) | 0 (0.0) |
| Thrombocytopenia | 4 (1.6) | 1 (0.4) | 0 (0.0) |
| Mucositis | 46 (18.0) | 19 (7.4) | 7 (2.7) |
| Liver dysfunction | 39 (15.2) | 17 (6.6) | 11 (4.3) |
| Renal dysfunction | 18 (7.0) | 3 (1.2) | 1 (0.4) |
| Albuminuria | 28 (10.9) | 11 (4.3) | 5 (2.0) |
| Gingival hemorrhage | 54 (21.1) | 12 (4.7) | 0 (0.0) |
| Stool hemorrhage | 43 (16.8) | 11 (4.3) | 2 (0.8) |
| Hemoptysis | 27 (10.5) | 8 (3.1) | 3 (1.2) |
| Fatigue | 91 (35.5) | 32 (12.5) | 11 (4.3) |
| Weight loss | 23 (9.0) | 12 (4.7) | 1 (0.4) |
AEs, adverse events.