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. 2016 Feb 4;11(2):e0147871. doi: 10.1371/journal.pone.0147871

Fig 1. Kinetic analysis of the TCR TRBV-TRBC repertoire during the course of PbA infection.

Fig 1

(A) Experimental procedure showing the preparation of samples from both infected and non-infected mice, as well as the parallel analysis of mice during the course of the infection (“kinetic” samples) and at the time of ECM onset (“CM+” samples). Days post-infection (days p-i) indicate the time at which animals of the corresponding groups are sacrificed. Organs harvested for each group are indicated. (B) Modification of the TRBV-TRBC repertoire in spleen, blood and brain of B10.D2 mice during the course of Plasmodium berghei ANKA infection. Average DBV-BC perturbations across all TRBVs and individuals in each group (μμDBV-BC) in the spleen (black), the blood (red) and the brain (green) are shown for the control uninfected (CTR), day 3 p-i (d3), day 4 p-i (d4), day 5 p-i (d5), day 6 p-i (d6) and CM+ groups. DBV-BC perturbations were computed with ISEApeaks using CTR Spleen as the reference group.