Table 1. Estimated regression coefficient and 95% confidence interval of log perturbation values between infected and control groups in spleen and blood.
| TRBV | Group | D3 | D4 | D5 | D6 | CM+ |
|---|---|---|---|---|---|---|
| 1 | Spleen | 0.07 | 0.25 | 0.52 | 0.66 | 1.24 |
| [-0.46;0.6] | [-0.14;0.64] | [0.15;0.9]* | [0.27;1.05]** | [0.94;1.54]*** | ||
| Blood | -0.06 | -0.21 | -0.02 | 0.32 | 1.16 | |
| [-0.57;0.45] | [-0.62;0.21] | [-0.43;0.39] | [-0.11;0.75] | [0.84;1.47]*** | ||
| 2 | Spleen | 0.2 | 0.3 | 0.23 | 0.37 | 0.61 |
| [-0.22;0.61] | [-0.01;0.6] | [-0.06;0.53] | [0.07;0.68]* | [0.37;0.84]*** | ||
| Blood | 0.38 | 0.15 | 0.36 | 0.47 | 0.77 | |
| [-0.04;0.8] | [-0.18;0.47] | [0.03;0.7] | [0.11;0.83]* | [0.5;1.04]*** | ||
| 3 | Spleen | 0.09 | 0.1 | 0.54 | 0.72 | 1.02 |
| [-0.37;0.56] | [-0.25;0.44] | [0.21;0.87]* | [0.38;1.07]*** | [0.76;1.29]*** | ||
| Blood | -0.05 | 0.18 | 0.29 | 0.54 | 1.05 | |
| [-0.48;0.38] | [-0.16;0.53] | [-0.05;0.64] | [0.18;0.9]* | [0.78;1.32]*** | ||
| 4 | Spleen | 0.15 | 0.4 | 0.2 | 0.75 | 0.52 |
| [-0.38;0.68] | [0.01;0.79] | [-0.19;0.59] | [0.36;1.14]** | [0.22;0.82]** | ||
| Blood | 0.15 | 0.3 | 0.1 | 0.3 | 0.73 | |
| [-0.31;0.6] | [-0.06;0.66] | [-0.26;0.46] | [-0.08;0.68] | [0.45;1.01]*** | ||
| 5 | Spleen | 0.16 | 0 | 0.37 | 0.56 | 0.68 |
| [-0.27;0.59] | [-0.32;0.31] | [0.07;0.68]* | [0.25;0.88]** | [0.44;0.93]*** | ||
| Blood | -0.3 | -0.13 | -0.41 | 0.01 | 0.59 | |
| [-0.67;0.07] | [-0.43;0.17] | [-0.71;-0.12] | [-0.31;0.33] | [0.35;0.82]*** | ||
| 12–1 | Spleen | -0.41 | -0.15 | 0.03 | 0.31 | 0.14 |
| [-0.9;0.09] | [-0.51;0.21] | [-0.32;0.38] | [-0.05;0.67] | [-0.14;0.41] | ||
| Blood | 0.11 | 0.06 | 0.56 | 0.32 | 0.5 | |
| [-0.29;0.52] | [-0.29;0.4] | [0.21;0.9]* | [-0.07;0.7] | [0.23;0.77]*** | ||
| 12–2 | Spleen | -0.18 | -0.31 | 0.43 | 0.45 | 0.56 |
| [-0.72;0.37] | [-0.78;0.17] | [0.01;0.85] | [0.03;0.88] | [0.21;0.91]** | ||
| Blood | -0.03 | 0.1 | 0.49 | 0.46 | 0.76 | |
| [-0.6;0.54] | [-0.37;0.57] | [0.03;0.96] | [0.03;0.89] | [0.38;1.14]*** | ||
| 13–1 | Spleen | -0.22 | -0.37 | -0.16 | 0.22 | 0.28 |
| [-0.65;0.22] | [-0.69;-0.05] | [-0.47;0.15] | [-0.1;0.54] | [0.03;0.52]* | ||
| Blood | -0.25 | -0.01 | 0.21 | 0.03 | 0.61 | |
| [-0.71;0.21] | [-0.37;0.35] | [-0.18;0.59] | [-0.36;0.42] | [0.32;0.9]*** | ||
| 13–2 | Spleen | 0.12 | 0.38 | 0.27 | 0.59 | 0.41 |
| [-0.38;0.62] | [0.02;0.75] | [-0.09;0.62] | [0.22;0.96]** | [0.12;0.69]** | ||
| Blood | 0.22 | 0.07 | 0.26 | 0.31 | 0.19 | |
| [-0.19;0.63] | [-0.25;0.39] | [-0.07;0.6] | [-0.05;0.67] | [-0.07;0.45] | ||
| 13–3 | Spleen | 0 | 0.05 | 0.15 | 0.4 | 0.49 |
| [-0.4;0.4] | [-0.24;0.35] | [-0.14;0.43] | [0.1;0.69]* | [0.27;0.72]*** | ||
| Blood | 0.24 | 0.02 | 0.09 | 0.37 | 0.43 | |
| [-0.18;0.65] | [-0.3;0.34] | [-0.25;0.42] | [0.01;0.73] | [0.17;0.69]** | ||
| 14 | Spleen | -0.13 | 0 | 0.17 | 0.07 | 0.05 |
| [-0.45;0.19] | [-0.24;0.23] | [-0.07;0.42] | [-0.17;0.3] | [-0.14;0.23] | ||
| Blood | -0.04 | -0.08 | -0.1 | 0.03 | -0.06 | |
| [-0.35;0.26] | [-0.32;0.17] | [-0.35;0.15] | [-0.23;0.3] | [-0.26;0.14] | ||
| 15 | Spleen | -0.17 | 0.16 | 0.17 | 0.26 | 0.73 |
| [-0.69;0.35] | [-0.24;0.56] | [-0.19;0.54] | [-0.13;0.66] | [0.43;1.02]*** | ||
| Blood | -0.18 | -0.26 | 0.17 | 0.58 | 0.61 | |
| [-0.67;0.31] | [-0.64;0.12] | [-0.23;0.56] | [0.15;1.01]* | [0.29;0.92]*** | ||
| 16 | Spleen | 0.09 | -0.02 | 0.12 | 0.05 | 0.11 |
| [-0.24;0.42] | [-0.27;0.23] | [-0.12;0.36] | [-0.19;0.3] | [-0.07;0.3] | ||
| Blood | -0.27 | -0.17 | -0.29 | -0.07 | 0.11 | |
| [-0.58;0.03] | [-0.41;0.08] | [-0.55;-0.04] | [-0.32;0.19] | [-0.08;0.3] | ||
| 17 | Spleen | 0.4 | 0.34 | 0.24 | 0.19 | 0.5 |
| [-0.13;0.93] | [-0.09;0.76] | [-0.14;0.61] | [-0.19;0.57] | [0.19;0.81]** | ||
| Blood | 0.2 | -0.06 | 0.07 | 0.07 | 0.36 | |
| [-0.29;0.68] | [-0.45;0.33] | [-0.35;0.49] | [-0.34;0.48] | [0.04;0.68]* | ||
| 19 | Spleen | 0.2 | 0.19 | 0.49 | 0.64 | 0.55 |
| [-0.27;0.67] | [-0.15;0.54] | [0.14;0.83]* | [0.3;0.98]** | [0.29;0.81]*** | ||
| Blood | -0.02 | 0.37 | 0.17 | 0.7 | 0.56 | |
| [-0.45;0.41] | [0.04;0.71] | [-0.18;0.52] | [0.33;1.06]** | [0.29;0.83]*** | ||
| 20 | Spleen | -0.2 | 0.17 | 0.44 | 0.63 | 0.44 |
| [-0.69;0.29] | [-0.19;0.53] | [0.09;0.79]* | [0.26;0.99]** | [0.16;0.73]** | ||
| Blood | 0.38 | 0.14 | -0.12 | 0.1 | 0.63 | |
| [-0.16;0.91] | [-0.28;0.56] | [-0.58;0.33] | [-0.37;0.56] | [0.28;0.98]** | ||
| 23 | Spleen | 0.24 | 0.38 | 0.43 | 0.55 | 0.61 |
| [-0.21;0.68] | [0.05;0.71] | [0.12;0.74]* | [0.22;0.87]** | [0.36;0.85]*** | ||
| Blood | -0.02 | 0.06 | 0 | 0.35 | 0.63 | |
| [-0.5;0.45] | [-0.31;0.43] | [-0.38;0.38] | [-0.04;0.75] | [0.32;0.95]*** | ||
| 26 | Spleen | 0.15 | 0.03 | 0.75 | 1.05 | 0.75 |
| [-0.29;0.59] | [-0.3;0.36] | [0.44;1.07]*** | [0.72;1.38]*** | [0.5;1]*** | ||
| Blood | 0.3 | -0.25 | 0.03 | 0.7 | 1.24 | |
| [-0.19;0.8] | [-0.63;0.13] | [-0.39;0.44] | [0.29;1.11]* | [0.92;1.55]*** | ||
| 29 | Spleen | -0.34 | -0.22 | 0.09 | 0.5 | 0.56 |
| [-0.85;0.18] | [-0.6;0.15] | [-0.28;0.45] | [0.12;0.87]* | [0.27;0.85]*** | ||
| Blood | 0.04 | -0.11 | 0.17 | 0.49 | 0.74 | |
| [-0.41;0.48] | [-0.43;0.2] | [-0.15;0.5] | [0.12;0.85]* | [0.48;0.99]*** | ||
| 30 | Spleen | 0.33 | 0.16 | 0.37 | 0.71 | 0.28 |
| [-0.18;0.83] | [-0.22;0.53] | [0.01;0.73] | [0.34;1.09]** | [-0.01;0.58] | ||
| Blood | 0.21 | -0.06 | 0.25 | 0.42 | 0.36 | |
| [-0.3;0.71] | [-0.46;0.35] | [-0.14;0.64] | [0;0.85] | [0;0.71] | ||
| 31 | Spleen | -0.09 | 0.08 | 0.51 | 0.34 | 0.41 |
| [-0.55;0.37] | [-0.26;0.41] | [0.18;0.84]* | [-0.01;0.68] | [0.16;0.67]** | ||
| Blood | 0.3 | 0.02 | 0.11 | 0.03 | 0.49 | |
| [-0.19;0.79] | [-0.37;0.4] | [-0.3;0.51] | [-0.38;0.44] | [0.18;0.8]** |
*** adjusted p<0.001
** adjusted p<0.01
* adjusted p<0.05