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. 2016 Feb 4;11(2):e0148207. doi: 10.1371/journal.pone.0148207

Fig 5. Dynamic follow-up of the Treg/Th17 ratio, serum ACE and FEV1% and DLco% predicted values in pulmonary sarcoidosis patients.

Fig 5

(A) The Treg/Th17 ratio decreased, accompanied by an elevation in the serum ACE level and decreases in the FEV1% and DLco% predicted values over the nine months of follow-up after the end of treatment in the first relapse patient; then, the Treg/Th17 ratio dramatically increased, accompanied by a decrease in the serum ACE level and increases in FEV1% and DLco% predicted values over the first 3 months of retreatment. Over the 12 months of follow-up, these values stabilized. (B) The Treg/Th17 ratio decreased over 6 months of follow-up after the end of treatment, without distinct changes in the serum ACE or FEV1% and DLco% predicted values in another relapse patient; then, the Treg/Th17 ratio slightly increased over the first 3 months of retreatment, with symptom remission at 12 months of follow-up. (C) The Treg/Th17 ratio, serum ACE and FEV1% and DLco% predicted values remained stable before the end of prednisone treatment in a stable patient; all of these parameters remained stable without clinical symptoms over the subsequent 12 months.