Table 2.

PET studies examining microglial activation in schizophrenia

Study	Sample	Mean age (years)	Mean DOI (years)	Radioligand	BP results	Correlations
van Berckel et al. (2008)	10 patients	24	3.1	[11C]‐(R)‐PK11195	↑ BP in whole brain in patients
	10 controls	23
Banati and Hickie (2009)	16 patients	39.4	3 months–30 years (range)	[11C]‐(R)‐PK11195	↑ BP 15 of 28 regions. More marked on the right side.
	8 controls	37.6
Doorduin et al. (2009)	7 recovering from psychosis	31.3	5.3	[11C]‐(R)‐PK11195	↑ BP in the HPC of patients.
	7 controls	26.8			30% ↑ BP in whole‐brain GM and WM.
Takano et al. (2010)	14 patients	43.9	18.8	[11C]‐DAA1106	≈ in BP	Relationship between BP and age, DOI, duration of drug treatment and positive symptom scores in patients.
	14 controls	42.5
Kenk et al. (2015)	16 patients	42.5	14.8	[18F]‐FEPPA	≈ in BP	Positive correlation between BP and number of acute crises in the striatum.
	27 controls	43.5

^≈ No between‐group difference.

^↑ Increased in schizophrenia.

^↓ Decreased in schizophrenia.

DOI, duration of illness.