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CAR T cell production and use. Peripheral blood mononuclear cells (PBMCs) are collected from the patient via apheresis and stimulated PMBCs are exposed to the viral or non-viral vector. T cells are stimulated using anti-CD3/anti-CD28 monoclonal antibody-coated magnetic beads with or without additional exogenous cytokines. Patients then receive lymphodepleting chemotherapy followed by infusion of CAR T cells.
