Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 23;7(2):100–113. doi: 10.1007/s13238-015-0212-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Regulation of let-7 biogenesis by LIN28A/B. LIN28A and LIN28B inhibit the biogenesis of let-7 via both TUTase-dependent and -independent pathways. LIN28A helps TUTases to oligo-uridylate pre-let-7. Methylated LIN28A binds to pri-let-7 in the nucleus and sequesters it into the nucleolus to prevent Drosha-mediated processing. LIN28B blocks the biogenesis of the let-7 miRNA via TUTase-independent pathways. The detailed relationship between LIN28B and TUTases needs to be further understood