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. 2015 Sep 8;7(2):89–99. doi: 10.1007/s13238-015-0199-4

Table 1.

miRNAs aberrantly expressed and validated target genes in BCSCs

miRNA Expression Targets Function References
let-7 Down H-Ras, HMGA2 Reduce BCSCs Yu et al. (2007)
miR-200c Down BMI1 Reduce BCSCs Shimono et al. (2009)
miR-200b Down SUZ12 Reduce BCSCs Iliopoulos et al. (2010)
miR-93 Down AKT3, SOX4 and STAT3 Inhibit BCSCs in basal type cancer, promote BCSCs in luminal type cancer Liu et al. (2012)
miR-100 Down SMARCA5, SMARCD1 and BMPR2 Inhibit BCSCs Deng et al., (2014)
miR-141 Down Stat5a and PR Reduce BCSCs Finlay-Schultz et al. (2014)
miR-34c Down Notch4 Inhibit BCSCs Yu et al. (2012)
miR-30 Down Ubc9 and ITGB3 Inhibit BCSCs Yu et al. (2010)
miR-128 Down BMI1 and ABCC5 Inhibit BCSCs Zhu et al. (2011)
miR-140 Down ALDH1 and SOX9 Inhibit BCSCs Zhang et al. (2012)
miR-27a Down ZBTB10 Inhibit BCSCs Tang et al. (2014)
miR-27b Down ENPP1 Inhibit BCSCS Takahashi et al. (2015)
miR-7 Down KLF4, SETDB1 Inhibit BCSCs Okuda et al. (2013); Zhang et al. (2014a)
miR-34a Down Notch1 Reduce BCSCs Park et al. (2014)
miR-142 Up APC Promote BCSCs Isobe et al. (2014)
miR-21 Up PTEN, AKT and ERK1/2 pathways promote BCSCs Han et al. (2012a, b, c)
miR-29 Up Non report Promote BCSCs Li et al. (2014)
miR-495 Up E-Cadherin Promote BCSCs Hwang-Verslues et al. (2011)
miR-181 Up ATM Promote BCSCs Finlay-Schultz et al. (2014)
miR-22 Up TET-family proteins Promote BCSCs Song et al. (2013)
miR-221 Up ATXN1 Promote BCSCs Ke et al. (2015)
miR-9 Up Non-report Promote BCSCs Gwak et al. (2014)