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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Nat Prod Rep. 2016 Feb 4;33(2):150–161. doi: 10.1039/c5np00112a

Figure 3.

Figure 3

Biosynthesis of newly identified PKS starter units. (A) Biosynthesis of p-nitrobenzoic acid (pNBA), the starter unit for aureothin (3) biosynthesis. (B) Biosynthesis of the L-proline derived starter units pyrrolyl-CP (5) and 4,5-dichloropyrrolyl-CP (8). (C) Biosynthesis of the L-arginine derived starter unit 4-guanidinobutyryl-CoA (12). (D) Biosynthesis of 5-hexynoyl-ACP (16) for (I) incorporation into jamaicamide (17) and (II) utilization of its biosynthetic pathway for the bioengineering of an antimycin analogue (19). In this figure and all others in this article, we highlight the unusual starter unit and extender unit derived atoms in red and blue, respectively.