. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Clin Exp Metastasis. 2015 Oct 27;33(1):53–62. doi: 10.1007/s10585-015-9757-7

Table 2.

Average continuous EMT marker expression in tumor tissue compared to non-neoplastic adjacent tissue

Marker	Algorithm	Scale	Tissue type	N	Marker expression
					Weighted average^a			Worst core^b
					Mean	SD	P value	Mean	SD	P value
E-cadherin	Membrane + cytoplasm	Average intensity (0–3)	Tumor Non-neoplastic	188 181	0.84 0.98	0.22 0.22	<0.0001	0.74 0.87	0.24 0.28	<0.0001
Snail	Nuclear^c	Percent positive nuclei (0–100)	Tumor Non-neoplastic	185 173	41.7 47.9	22.1 27.9	0.02	52.3 62.1	24.9 27.2	0.0004

Marker expression values assigned as weighted average of cores by tissue type (weighted by area analyzed for E-cadherin and number of nuclei for Snail)

Marker expression values assigned as expression by tissue type of the core with lowest expression for E-cadherin and highest expression for Snail

First nuclear Snail algorithm of the multiple Snail scoring algorithms that were developed