Table 3.

Statistically-optimal dichotomous EMT marker expression status cross-tabulated with tumor stage and with risk of dying within 5 years of surgery

	E-cadherin				Snail
	Weighted Averagea		Worst Coreb		Weighted Averagea		Worst Coreb
	Low	High	Low	High	Low	High	Low	High
Stage
Local	6	93	3	96	29	69	54	44
Regional	5	61	3	63	14	51	45	20
Distant	0	23	0	23	1	21	13	9
Mortality risk
Died within 5 years (x)	7	55	3	59	17	44	43	18
Total at risk (y)	11	177	6	182	44	141	112	73
5-Year risk of death post-surgery (%) (x/y)	64	31	50	32	39	31	38	25

Of 190 overall subjects in the EMT study, the number with tumor tissue marker data available was 188 for E-cadherin and 185 for Snail Low expression status is expression in tumor tissue below the statistically-optimal cut point and high expression status is expression in tumor tissue at or above the statistically-optimal cut point. The a priori hypotheses were that low E-cadherin subjects would have worse outcomes while high Snail subjects would have worse outcomes. For the value of the statistically-optimal cut point for each marker expression variable, see “Materials and methods” section

^aMarker expression values assigned as weighted average of cores in tumor tissue (weighted by area analyzed for E-cadherin and number of nuclei for Snail)

^bMarker expression values assigned as expression in tumor tissue of the core with lowest expression for E-cadherin and highest expression for Snail