Table 5.
Flow-mediated dilatation: baseline vessel diameter and percentage change throughout study
| Time point | Allopurinol (95% CI) | Placebo (95% CI) | P |
|---|---|---|---|
| Baseline vessel size prior to cuff inflation, mm | 4.66 (4.34-4.98) | 4.24 (3.75-4.73) | 0.14 |
| Absolute change post-cuff at visit 2 (initial visit), mm | 0.38 (0.25-0.51) | 0.34 (0.19-0.50) | 0.65 |
| Relative change post-cuff at visit 2 (initial visit), mm | 8.33 (5.87-10.79) | 9.61 (4.92-14.30) | 0.84 |
| Absolute change post-cuff at visit 5, mm | 0.24 (0.16-0.31) | 0.24 (0.13-0.34) | 0.66 |
| Relative change post-cuff at visit 5, % | 4.85 (3.46-6.24) | 5.61 (3.54-7.69) | 0.32 |
| Relative change compared with baseline post-cuff at visit 5, % | −0.29 (−0.53 to −0.06) | −0.15 (−0.59 to 0.28) | 0.42 |
| Absolute change post-cuff at visit 6, mm | 0.41 (0.30-0.52) | 0.25 (0.14-0.36) | 0.06 |
| Relative change post-cuff at visit 6, % | 8.92 (6.43-11.40) | 6.55 (3.49-9.61) | 0.27 |
| Relative change compared with baseline post-cuff at visit 6, % | 0.41 (−0.30 to 1.11) | −0.28 (−0.64 to 0.09) | 0.32 |
“Post-cuff” indicates the measurement of maximal vessel size that was made immediately following deflation of the blood pressure cuff.
CI, confidence interval.