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. 2016 Feb 3;89(3):645–657. doi: 10.1016/j.neuron.2016.01.008

Figure 3.

Figure 3

Modular Organization of Nucleocortical Projections

(A) Experimental setup to investigate the relation between nucleocortical afferents and zonal marker Zebrin II.

(B) Distribution of nucleocortical MF (green) in relation to Zebrin II (red) expression at the trough of the simplex lobule (B1) and the border between Zebrin II positive (Z+) and negative (Z−) zones in Crus 1 (B2).

(C) Quantification of the nucleocortical MF terminating at the Z− zones in Crus 1 (90.5% ± 3.3%), Crus 2 (88.5% ± 6.2%), and the lobule simplex (93.7 ± 2.8%), N = 4.

(D) Experimental setup to investigate relation of nucleocortical afferents and CF zones. The arrowheads indicate the tracing directions.

(E) BDA 10,000 Da and Ctb 555 injection in the anterior IpN labeled cortical modules (between dashed lines) in the lobule simplex (Sim) (E1). Nucleocortical MF and PC are co-localized in the same module (E2). The PC soma and adjacent CF were labeled with CTb (yellow, arrowheads), and the nucleocortical MF was labeled with BDA (green, asterisk). The data show mean ± SE.