Figure 5.

Molecular details of the OSCAR:THP-binding sites. Hydrophilic interfaces between DB316 and OSCAR D1 and D2, panels A and B, respectively; hydrophobic interfaces with semitransparent surfaces between DB316 and OSCAR D1 and D2, panels C and D, respectively. Protein and peptide are shown in cartoon, whereas residues involved in hydrophilic or hydrophobic interactions are emphasized by rendering as sticks. OSCAR ectodomain is colored cyan whereas leading, middle, and trailing strands of DB316 are colored green, yellow, and gray, respectively. Hydrogen bonds and distances (labeled and measured in Å) from center of phenylalanine benzyl rings are indicated by yellow dotted lines.