Table 3.
Top nonoverlapping pathways enriched in SNPs associated with osteonecrosis (meta-analysis P < .001) in combined discovery and replication cohorts (1186 total patients)
| Pathway (P for enrichment) | Gene | Top SNP(s) tagged to gene* | Meta-analysis P value of top SNP(s) |
|---|---|---|---|
| Glutamate receptor signaling (P = 9.91 × 10−4) | GRID2 | rs34144324 | 7.07 × 10−7 |
| GRM5 | rs308894 | 1.09 × 10−4 | |
| GRM7 | rs112943394, rs112050403 | 1.22 × 10−4 | |
| GRIN2B | rs1805491 | 4.21 × 10−4 | |
| GNG7 | rs71339112 | 9.74 × 10−4 | |
| SLC17A6 | rs7127241 | 4.79 × 10−4 | |
| Adipogenesis (P = .015) | BMP7 | rs79085477, rs75161997 | 8.28 × 10−9 |
| EBF1 | rs71593317 | 1.26 × 10−6 | |
| NR1D2 | rs62253386, rs62253388 | 4.07 × 10−5 | |
| CTBP1 | rs2306475 | 3.27 × 10−4 | |
| SOX9 | rs17224938 | 7.39 × 10−4 | |
| FZD10 | rs10773748 | 1.82 × 10−5 | |
| BMP2 | rs117896134 | 3.16 × 10−4 |
*
Multiple SNPs in full LD are shown if all have equal associations with osteonecrosis.