Figure 3.

Operon Gene Order Reflects the Order of Protein Complex Assembly

(A) Illustration of the three possible relationships between gene pair order and subunit assembly order.

(B) Evolutionary conservation in pairs of adjacent genes encoding subunits of the same complex. The p values were calculated with Fisher’s exact test. Error bars represent 68% Wilson binomial confidence intervals.

(C) When considering adjacent gene pairs with evolutionarily conserved gene order that encode different subunits of the same protein complex, the predicted assembly order is the same as the gene order in 57 of 72 cases. The p value was calculated with a binomial test.