Figure 3.

LRRC19 Deficiency Affects Maturation of Gut-Associated Lymphoid Tissues

(A and B) Visible PP number (A) and sizes (B) in the guts of WT and Lrrc19 KO mice.

(C) Absolute numbers of CD4⁺T cells, CD8⁺ T cells, CD11c⁺MHCII⁺ cells, F4/80⁺MHCII⁺ cells, and CD11b⁺Gr1⁺ cells in colon tissues. The absolute numbers were standardized by calculating the numbers per l cm of colon.

(D) Numbers of CD11c⁺CD103⁺CD11b⁻DCs (pp-CD103⁺DC), CD11C⁺CD103⁺CD11b⁺ DCs (PP-DP-DC), CD11C⁺CD11b⁻CD103⁻DCs (PP-DNDC), and CD11C⁺CD11b⁺ (PP-CD11b⁺DC) in PPs as assessed by flow cytometry analysis.

(E and F) Number of CD4⁺, CD8⁺, CD4⁺Foxp3⁺, CD4⁺IL-17⁺, and CD4⁺IFNγ⁺ T cells in PPs (E) and MLNs (F). Cell numbers in age- and sex-matched WT (n = 6) and Lrrc19 KO (n = 6) mice were compared.

^∗p < 0.05, ^∗∗p < 0.01 (Mann-Whitney U test). The data are representative of three independent experiments. See also Figures S2 and S3.