Table 3. Univariate and multivariate analyses of prognostic variables.

	OS univariate analysis	OS multivariate analysis		PFS univariate analysis	PFS multivariate analysis
Variable	P-value	HR (95% CI)	P-value	P-value	HR (95% CI)	P-value
Gender	0.880	0.803 (0.496–1.298)	0.370	0.807	0.856 (0.553–1.325)	0.486
Age	0.656	1.008 (0.597–1.703)	0.975	0.676	1.060 (0.663–1.694)	0.809
Smoking	0.497	1.309 (0.704–2.435)	0.395	0.922	1.116 (0.625–1.993)	0.712
Drinking	0.105	0.980 (0.523–1.837)	0.949	0.134	1.009 (0.565–1.802)	0.976
T stage	<0.001*	1.355 (1.019–1.802)	0.037*	<0.001*	1.385 (1.061–1.808)	0.017*
N stage	0.001*	1.462 (1.128–1.897)	0.004*	0.001*	1.371 (1.081–1.738)	0.009*
Differentiation	0.079	0.868 (0.654–1.153)	0.329	0.100	0.908 (0.702–1.173)	0.460
Adequate therapy	0.021*	1.703 (1.023–2.837)	0.041*	0.009*	1.723 (1.083–2.741)	0.022*
miR-146a	0.017*	0.538 (0.317–0.915)	0.022*	0.004*	0.491 (0.302–0.801)	0.004*

Abbreviations: CI=confidence interval; HR=hazard ratio; miR-146a=microRNA-146a; PFS=progression-free survival; OS=overall survival.