Table 1.
Demographic Characteristics and Underlying Conditions of Nonprosthetic Candida Arthritis (N = 112)
| Demographic Features and Underlying Conditions | N (%) |
|---|---|
| Median age (neonates-84 years) | 40 years |
| Adults (≥19 years) | 72 (64) |
| Pediatric population | 40 (36) |
| Neonates (≤1 months) | 11 (10) |
| Infants (≤12 months) | 17 (15) |
| Toddlers/Children (1–18 years) | 10 (9) |
| Unknown age | 2 (2) |
| Gender | |
| Females | 37 (33) |
| Males | 69 (62) |
| Unknown | 6 (5) |
| Underlying conditions | |
| Solid tumors | 5 (4) |
| Hematologic malignancy | 18 (16) |
| Aplastic anemia | 1 (1) |
| Solid organ transplantation | 10 (9) |
| Bone marrow transplantation | 3 (3) |
| Surgery | 39 (35) |
| Facial/Neck | 0 (0) |
| Thoracic | 4 (4) |
| Abdominal | 20 (18) |
| Orthopedic | 15 (13) |
| Prior broad-spectrum antibiotics | 73 (65) |
| Prior antifungal agents | 35 (31) |
| Central venous catheter | 17 (15) |
| Open fracture | 0 (0) |
| Trauma/open wound | 10 (9) |
| HIV | 4 (4) |
| IVDU | 10 (9) |
| Alcohol abuse | 5 (4) |
| Hemodialysis | 6 (5) |
| Neutropenia | 10 (9) |
| Corticosteroids | 20 (18) |
| Pharmacological immunosuppression other than steroids | 19 (17) |
| Hypogammaglobulinemia | 2 (2) |
| Chronic Pulmonary Disease | 4 (4) |
| Abdominal abscess | 1 (1) |
| GI rupture | 1 (1) |
| Necrotic enterocolitis | 2 (2) |
| Congenital disorder (gastroschisis, Hirschsprung's disease) | 7 (6) |
| Total parenteral nutrition | 14 (13) |
| Diabetes mellitus | 11 (10) |
| Rheumatoid arthritis | 2 (2) |
| Intensive care unit | 6 (5) |
| None | 3 (3) |
| Preexisting invasive candidiasis | 71 (63) |
| Candidemia | 32 (29) |
| Other forms of candidiasisa | 39 (35) |
| Candidemia at time of diagnosis of Candida arthritis | 12 (11) |
Abbreviations: CNS, central nervous system; GI, gastrointestinal; HIV, human immunodeficiency virus;IVDU, intravenous drug use.
a Central venous catheter infection, candiduria, orbital candidiasis, and otitis, cutaneous, pulmonary, or CNS infection.