Table 7.
Treatment and Outcome of Nonprosthetic Candida Arthritis
| Treatment and Outcome | N (%) |
|---|---|
| Medical Treatmenta | |
| Only antifungal agents | 69 (62) |
| Only surgery | 1 (1) |
| Antifungal agents and surgery | 40 (36) |
| Class of Antifungal Agent(s) Used | |
| Amphotericin B | 37 (33) |
| Triazoles | 21 (19) |
| Flucytosine | 8 (7) |
| Combinationsb | 43 (38) |
| Duration of Medical Treatmentc | |
| Median duration in days (range, 14–436) | 64 days |
| Surgical Intervention | |
| Debridement | 28 (25) |
| Drainage/aspiration | 13 (12) |
| Irrigation/lavage | 11 (10) |
| Amputation | 3 (3) |
| Bone grafting | 1 (1) |
| Insertion of metal hardware/prosthesis/arthroplasty | 1 (1) |
| Outcome | |
| Complete response | 87 (78) |
| Partial response | 21 (19) |
| Failure | 4 (4) |
| Relapse | 18 (16) |
| Overall mortality | 15 (13) |
a Two cases received no therapy.
b Among the 43 cases of combination antifungal therapy, the following classes were used: polyene-azole (20), polyene-flucytosine (13), polyene-azole-flucytosine (3), azole-flucytosine (1), azole-echinocandin (2), polyene-azole-echinocandin (3), and polyene-echinocandin (1).
c Forty-six cases of unknown duration.