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. 2015 Dec 23;3(1):ofv207. doi: 10.1093/ofid/ofv207

Table 8.

Effect of Age on Effect by Site of Infection, Clinical Manifestations, and Outcome in Candida Arthritis

Population (N) Mechanism (N) Joint Sites (N) Number of Sites Infected/Patient (N) Clinical Manifestations (N) Therapeutic Intervention (N) Outcome (N)

  • All pediatric patients (40)

  • Neonates (11)

  • Hemato (5)

  • HSCT (2)

  • Hematogenous (38)*

  • Contiguous (0)

  • Direct inoculation (2)

  • Knee (31)

  • Hip (10)

  • Ankle (5)

  • Elbow (4)

  • Shoulder (3)

  • Others (4)

  • Wrist (1)

  • Carpus (1)

  • Costochondral (1)

  • Intervertebral (1)

  • 1 bone involved (20)

  • 2 bones involved (5)

  • ≥3 bones involved (15)

  • Local symptoms

  • pain (22)

  • Edema (31)

  • Erythema (6)

  • Limitation of movement (20)

  • Fever (7)

  • Draining pus (2)

  • Only AFT (28)

  • Only Surgery (0)

  • AFT + Surgery (11)

  • Debridement (4)

  • Amputation (1)

  • Drainage (5)

  • Lavage (4)

  • CR (35)

  • PR (5)a

  • Rel (3)

  • D (2)

  • Amphotericin (29)

  • Azoles (9)

  • 5-FC (14)

  • Echinocandins (2)

  • Adults (72)

  • Hematol (13)

  • HSCT (1)

  • SOT (10)

  • Hematogenous (53)*

  • Contiguous (0)

  • Direct inoculation (19)

  • Knee (53)

  • Hip (7)

  • Shoulder (5)

  • Others (11)

  • Intervertebral (4)

  • Carpus (2)

  • Tarsus (2)

  • Wrist (1)

  • Ankle (1)

  • Elbow (1)

  • 1 bone involved (57)

  • 2 bones involved (5)

  • ≥3 bones involved (10)

  • Local symptoms

  • pain (70)

  • Edema (48)

  • Erythema (19)

  • Limitation of movement (24)

  • Fever (8)

  • Draining pus (4)

  • Only AFT (41)

  • Only Surgery (1)

  • AFT + Surgery (29)

  • Debridement (24)

  • Amputation (2)

  • Drainage (8)

  • Lavage (7)

  • CR (52)

  • PR (16)

  • F (4)

  • Rel (15)

  • D (13)

  • Amphotericin (48)

  • Azoles (41)

  • 5-FC (11)

  • Echinocandins (4)

Abbreviations: AFT, antifungal therapy; CR, complete response; Hematol, hematological malignancies; HSCT, hematopoietic stem cell transplantation; PR, partial response; Rel, relapsed; D, death; SOT, solid organ transplantation; 5-FC, 5-fluorocytosine.

a Of the 5 patients with PR, 2 patients ultimately died.

* P = .005.