FIGURE 7.

Inhibition of recombinant ASIC1a channels by sMamb-1 variants. Alanine scanning of residues located in or close to the finger II region of sMamb-1. Dose-response curves (% of control current) of the inhibition of homomeric rat ASIC1a channels expressed in Xenopus oocytes by sMamb-1 and its variants. See Table 4 for IC₅₀ values and Hill slopes of the sigmoidal fits shown (n = 4–10). For clarity, curves have been split in two panels and the same curve for sMamb-1, which is different from the one shown in Fig. 3 (see legend Table 4), is included in both panels.