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Regulation of host transcriptome by M. tuberculosis WhiB3. PMA-differentiated THP-1 cells were infected with WT M. tuberculosis and MtbΔwhiB3. At the indicated time points, total RNA from THP-1 was isolated and transcriptomic analysis was done, as described under “Experimental Procedures.” The figure shows a heat map of major pathways differentially regulated in MtbΔwhiB3 as compared with M. tuberculosis, >1.5-fold (p < 0.05).
