FIGURE 4.
Single-channel parameters of Kv7 pore modules in the absence or presence of retigabine. A–E, single-channel Po (A), median burst length (B), mean open time (C), and mean closed times (τ1 closed and τ2 closed) of the indicated Kv7 PMs in the absence (black columns) or presence (blue columns) of 10 μm RTG (D and E). All experiments were performed in 0.5 m KCl, 10 mm HEPES (pH 7.4) at +100 mV. Calculated values are presented as mean ± S.E. Statistical analysis was performed by Student's t test. p > 0.05 indicates that two groups in question are not significantly different (ns). *, p < 0.05; **, p < 0.01; ***, p < 0.001.