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. Author manuscript; available in PMC: 2017 Feb 3.
Published in final edited form as: Neuron. 2016 Feb 3;89(3):449–460. doi: 10.1016/j.neuron.2015.12.023

Figure 3.

Figure 3

A working model of SARM1 auto-inhibition and activation upon injury. TOP: SARM1 is made up of three regions: 1) an auto-inhibitory N terminus (Nterm) comprised of multiple armadillo repeat motifs, 2) tandem SAM domains that mediate SARM1-SARM1 binding (SAMx2), and 3) a TIR domain that triggers axon degeneration upon multimerization. BOTTOM: SARM1 multimers are inactive (auto-inhibited) in uninjured axons. Injury leads to SARM1 activation, perhaps through release of inhibition, exposing TIR domain multimers that transmit a pro-destructive signal to unknown effector molecule(s).