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. 2016 Feb 5;6:20113. doi: 10.1038/srep20113

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Human non-small cell lung cancer (NSCLC) cell lines (n = 105) were separated into two groups that have high RNA expression of SOX2 (HIGH, n = 20) or low expression of SOX2 (LOW, n = 85). The expression of previously reported SOX2 downstream or correlated genes was assessed as to whether the expression of those genes was correlated with that of SOX2. Two-tailed Welch’s t-test was used to determine the significance of gene expression between the two groups. Genes with significantly higher expression in the HIGH group (p < 0.05 and average expression >1) were considered as SOX2 positively correlated genes, while genes with significantly higher expression in the LOW group (p < 0.05 and average expression >1) were considered as SOX2 negatively correlated genes. The expression was measured in RPKM and quantile normalized. Results represent the mean ± S.E.M. *indicates p < 0.05, **indicates p < 0.01, and ***indicates p < 0.001.