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. 2016 Feb 5;6:20189. doi: 10.1038/srep20189

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Copyright © 2016, Macmillan Publishers Limited

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To analyze the effects of BKM-120 in vivo, we injected U1242 cells intracranially in nude mice and treated them daily with 2 mg/kg and 20 mg/kg of BKM-120 by gavage. (A) Average of the the tumors perimeters measured at day 7, and corrected for the averages of the size of the tumors at day 4. (B) Tumor spread was examined using Vimentin and DAPI staining. Photographs illustrate tumor growth (low resolution, bar = 1 mm) and the tumor normal brain interface indicating the degree of invasion (high resolution, bar = 20 μm). One-way ANOVA was used for statistical analysis (**p < 0.01, ***p < 0.001).