Figure 2. Polyhydramnios occurred in Lrp4^−/− embryos at E18.5.

(a) Myometrium was removed from embryo. A representative Lrp4^−/− embryo with massive polyhydramnios and a littermate wild-type embryo are shown. (c–e) Lrp4^−/− foetuses (c,d,e) with bilateral (e) or unilateral (d) without (c) kidney agenesis and a wild-type littermate (b). a: adrenal gland, k: kidney, o- ovary, t: testis