Table 3. Metabolite level comparison between survivors (S) and non-survivors (NS) at day 1 and at day 7 for the 28-day and 90-day mortality.
| METABOLITE | S | NS | pValue | FDR | NS vs S | ||
|---|---|---|---|---|---|---|---|
| 28 day mortality | D1 | LPC a C16:1 | 0.657 (0.334, 0.970) | 0.313 (0.291, 0.591) | 0.040 | 0.003 | ↓ |
| PC aa C30:2 | 0.005 (0.005, 0.026) | 0.099 (0.017, 0.147) | 0.046 | 0.005 | ↑ | ||
| PC aa C38:1 | 0.757 (0.499, 0.936) | 1.025 (0.886, 1.645) | 0.028 | <10−6 | ↑ | ||
| PC aa C38:6 | 164.022 (131.032,174.123) | 92.206 (47.999,137.945) | 0.033 | <10−6 | ↓ | ||
| PC ae C38:0 | 2.633 (2.418, 3.202) | 1.712 (1.124, 2.241) | 0.015 | <10−6 | ↓ | ||
| SM C20:2 | 0.095 (0.068, 0.121) | 0.055 (0.043, 0.088) | 0.048 | 0.001 | ↓ | ||
| C2 | 5.080 (3.369, 8.774) | 11.066 (8.189, 21.852) | 0.048 | 0.028 | ↑ | ||
| D7 | LPC a C16:0* | 47.046 (24.384, 58.821) | 18.150 (14.455, 33.212) | 0.048 | 0.001 | ↓ | |
| LPC a C18:0* | 10.807 (6.188, 14.137) | 5.684 (3.502, 7.111) | 0.040 | 0.003 | ↓ | ||
| LPC a C24:0* | 0.096 (0.086, 0.108) | 0.066 (0.062, 0.085) | 0.010 | <10−6 | ↓ | ||
| PC aa C32:3* | 3.486 (2.769, 4.240) | 2.019 (1.807, 2.486) | 0.028 | 0.001 | ↓ | ||
| PC aa C34:4* | 8.604 (6.879, 11.438) | 4.150 (3.464, 5.720) | 0.028 | <10−6 | ↓ | ||
| PC aa C36:4* | 615.675(487.555,717.315) | 369.822(340.428,463.466) | 0.048 | <10−6 | ↓ | ||
| PC ae C34:3 | 26.979 (20.127, 31.112) | 18.013 (15.057, 21.835) | 0.048 | 0.002 | ↓ | ||
| PC ae C40:1* | 1.633 (1.209, 1.706) | 0.844 (0.770, 1.230) | 0.010 | 0.012 | ↓ | ||
| PC ae C42:4 | 0.788 (0.679, 0.892) | 0.608 (0.487, 0.663) | 0.040 | <10−6 | ↓ | ||
| Kynurenine | 7.680 (4.965, 8.735) | 12.000 (8.745, 23.800) | 0.012 | <10−6 | ↑ | ||
| 90 day mortality | D1 | PC aa C36:6 | 2.109 (1.630 , 2.435) | 1.357 (0.957, 1.712) | 0.033 | 0.0001 | ↓ |
| PC aa C38:4 | 225.147 (180.141 , 297.671) | 142.022 (110.846, 217.886) | 0.040 | 0.0106 | ↓ | ||
| PC aa C38:6 | 165.706 (137.786, 182.901) | 107.441 (57.345, 152.421) | 0.033 | 0.0002 | ↓ | ||
| D7 | LPC a C16:0* | 20.493 (6.241, 28.505) | 12.308 (5.056, 16.828) | 0.048 | 0.0002 | ↓ | |
| LPC a C16:1 | 0.657 (0.314, 0.967) | 0.467 (0.304, 0.610) | 0.040 | <10−6 | ↓ | ||
| LPC a C18:0* | 4.363 (1.679, 6.895) | 2.707 (1.658, 4.038) | 0.040 | 0.0002 | ↓ | ||
| LPC a C24:0 * | 0.054 (0.051, 0.073) | 0.057 (0.045, 0.066) | 0.008 | <10−6 | ↑ | ||
| PC aa C32:2 | 22.073 (15.415, 30.845) | 18.334 (12.289, 21.833) | 0.033 | 0.0007 | ↓ | ||
| PC aa C32:3* | 2.629 (1.924, 3.040) | 1.826 (1.480, 2.195) | 0.008 | <10−6 | ↓ | ||
| PC aa C34:3 | 74.941 (47.836, 87.092) | 51.173 (38.172, 65.232) | 0.040 | 0.0002 | ↓ | ||
| PC aa C34:4* | 5.129 (2.8154, 5.778) | 2.938 (2.173, 3.918) | 0.006 | 0.0001 | ↓ | ||
| PC aa C36:4* | 827.639 (414.531, 919.064) | 461.559 (352.353, 563.834) | 0.023 | 0.0008 | ↓ | ||
| PC aa C36:5 | 51.571 (28.557, 62.269) | 24.106 (19.734, 33.696) | 0.019 | 0.0004 | ↓ | ||
| PC aa C36:6 | 2.110 (1.630, 2.435) | 1.357 (0.957, 1.712) | 0.023 | 0.0001 | ↓ | ||
| PC ae C32:2 | 4.658 (3.829, 5.043) | 3.726 (3.195, 4.541) | 0.040 | 0.0003 | ↓ | ||
| PC ae C38:0 | 2.633 (2.293, 3.450) | 2.167 (1.221, 2.341) | 0.033 | 0.0041 | ↓ | ||
| PC ae C40:1* | 0.911 (0.654, 1.276) | 0.683 (0.426, 1.031) | 0.008 | <10−6 | ↓ | ||
| PC ae C42:5 | 1.353 (1.068, 1.924) | 1.138 (0.958, 1.920) | 0.048 | 0.0006 | ↓ | ||
| PC ae C44:6 | 0.462 (0.296, 0.612) | 0.401 (0.275, 0.552) | 0.048 | 0.0004 | ↓ |
Only significant results are reported (p < 0.05, FDR < 0.15). Plasma concentrations are expressed in μM and shown as median (25, 75 percentiles). The arrows indicate that the metabolite concentration in NS group is lower (↓) or higher (↑) with respect to S group. The symbol * marks significant metabolites in both mortality groups.