Table 2. The impact of variants on BMI, waist circumference, and the waist-to-hip ratio.

SNP	Gene	Alleles	MAF	Traits	Model 1		Model 2
					BETA ± SE	P	BETA ± SE	P
rs984222	TBX15-WARS2	C/G	0.41	BMI	−0.0378 ± 0.0879	0.6672
				WC	−0.0021 ± 0.0012	0.0916	−0.0017 ± 0.0007	0.0211
				WHR	−0.0018 ± 0.0007	0.0151	−0.0016 ± 0.0007	0.0124
rs574367	SEC16B	T/G	0.2	BMI	0.5353 ± 0.1105	1.33 × 10−6a
				WC	0.0056 ± 0.0016	3.38 × 10−4b	−0.0005 ± 0.0009	0.6158
				WHR	0.0011 ± 0.0009	0.2196	−0.0007 ± 0.0008	0.373
rs4846567	LYPLAL1	T/G	0.3	BMI	0.192 ± 0.0939	0.0409
				WC	0.0021 ± 0.0013	0.1218	0.00002 ± 0.0008	0.9806
				WHR	−0.0007 ± 0.0008	0.3893	−0.0013 ± 0.0007	0.0681
rs6548238	TMEM18	T/C	0.09	BMI	−0.4554 ± 0.1546	0.0033
				WC	−0.0059 ± 0.0022	0.0066	−0.0009 ± 0.0013	0.4991
				WHR	−0.0022 ± 0.0013	0.0831	−0.0006 ± 0.0012	0.5786
rs1057001	TRIB2	T/A	0.15	BMI	0.0864 ± 0.1243	0.4873
				WC	0.0036 ± 0.0017	0.0413	0.0025 ± 0.0011	0.0169
				WHR	0.0020 ± 0.0010	0.0512	0.0016 ± 0.0009	0.0779
rs887912	FANCL	A/G	0.002	BMI	0.8386 ± 0.9268	0.3656
				WC	0.0197 ± 0.0130	0.131	0.0102 ± 0.0078	0.1953
				WHR	0.0166 ± 0.0076	0.0281	0.0137 ± 0.0069	0.0462
rs2535633	ITIH4-AS1	C/G	0.41	BMI	0.2331 ± 0.0889	0.0088
				WC	0.0035 ± 0.0013	0.0054	0.0008 ± 0.0008	0.2694
				WHR	0.0006 ± 0.0007	0.4327	−0.0002 ± 0.0007	0.7294
rs6931262	RREB1	T/C	0.2	BMI	−0.0923 ± 0.1097	0.3998
				WC	0.0007 ± 0.0015	0.6553	0.0018 ± 0.0009	0.0545
				WHR	0.0020 ± 0.0009	0.0294	0.0023 ± 0.0008	0.0042
rs6905288	VEGFA	G/A	0.26	BMI	0.2671 ± 0.1009	0.0081
				WC	0.0030 ± 0.0014	0.038	0.0001 ± 0.0009	0.9024
				WHR	0.0002 ± 0.0008	0.7774	−0.0007 ± 0.0008	0.3321
rs987237	TFAP2B	G/A	0.17	BMI	0.0810 ± 0.1148	0.4807
				WC	0.0027 ± 0.0016	0.0943	0.0020 ± 0.0010	0.0387
				WHR	0.0010 ± 0.0009	0.2777	0.0008 ± 0.0009	0.345
rs10968576	LRRN6C-LINGO2	G/A	0.21	BMI	0.0504 ± 0.1082	0.6416
				WC	−0.0009 ± 0.0015	0.5359	−0.0016 ± 0.0009	0.0901
				WHR	−0.0021 ± 0.0009	0.016	−0.0023 ± 0.0008	0.004
rs4074134	BDNF	A/G	0.44	BMI	−0.2247 ± 0.0884	0.0111
				WC	−0.0030 ± 0.0012	0.0156	−0.0006 ± 0.0008	0.4287
				WHR	−0.0011 ± 0.0007	0.1369	−0.0004 ± 0.0007	0.5953
rs671	ALDH2	A/G	0.22	BMI	−0.2932 ± 0.1052	0.0053
				WC	−0.0075 ± 0.0015	4.05 × 10−7c	−0.0042 ± 0.0009	1.96 × 10−6c
				WHR	−0.0020 ± 0.0009	0.022	−0.0010 ± 0.0008	0.2143
rs4771122	MTIF3	G/A	0.18	BMI	−0.0293 ± 0.1140	0.7969
				WC	−0.0018 ± 0.0016	0.2532	−0.0015 ± 0.0010	0.1289
				WHR	−0.0022 ± 0.0009	0.0173	−0.0021 ± 0.0008	0.0147
rs9939609	FTO	A/T	0.12	BMI	0.3047 ± 0.1361	0.0253
				WC	0.0037 ± 0.0019	0.0563	0.0004 ± 0.0012	0.6978
				WHR	0.0018 ± 0.0011	0.1168	0.0008 ± 0.0010	0.4545
rs17782313	MC4R	C/T	0.22	BMI	0.3600 ± 0.1051	0.0006d
				WC	0.0073 ± 0.0015	9.73 × 10−7c	0.0032 ± 0.0009	3.65 × 10−4e
				WHR	0.0028 ± 0.0009	0.0012	0.0016 ± 0.0008	0.0471
rs29941	KCTD15	C/T	0.24	BMI	0.2437 ± 0.1017	0.0166
				WC	0.0030 ± 0.0014	0.0344	0.0004 ± 0.0009	0.6586
				WHR	0.0010 ± 0.0008	0.2458	0.0001 ± 0.0008	0.8564
rs3810291	TMEM160	A/G	0.29	BMI	0.1594 ± 0.0984	0.1053
				WC	0.0025 ± 0.0014	0.0662	0.0008 ± 0.0008	0.3265
				WHR	0.0020 ± 0.0008	0.014	0.0015 ± 0.0007	0.0465
rs4823006	ZNRF3	A/G	0.46	BMI	−0.1732 ± 0.0884	0.0502
				WC	−0.0020 ± 0.0012	0.1013	−0.0002 ± 0.0008	0.7473
				WHR	−0.0016 ± 0.0007	0.0268	−0.0011 ± 0.0007	0.1052

SNP, single nucleotide polymorphism; Alleles, minor/major alleles; MAF minor allele frequency; SE, standard error; WC, waist circumference; WHR, waist-to-hip ratio.

Only SNPs that showed nominal significant associations with traits are shown in Table 2.

P values < 0.05 are shown in bold.

Traits were adjusted for age and sex in the additive genetic model 1 and adjusted for age, sex, and BMI in model 2.

^aEmpirical P = 0.0004.

^bEmpirical P = 0.0187.

^cEmpirical P = 1 × 10-4.

^dEmpirical P = 0.0326.

^eEmpirical P = 0.0209; Empirical P values were based on 10000 permutations within each trait.