Skip to main content
. 2016 Feb 5;6:20691. doi: 10.1038/srep20691

Table 3. Influence of variants on fat distribution (i.e., visceral fat and subcutaneous fat).

SNP Gene Alleles MAF Traits Model 1 Model 2
BETA ± SE P BETA ± SE P
rs574367 SEC16B T/G 0.2 VFA 0.0221 ± 0.0080 0.0055 −0.0031 ± 0.0061 0.6115
        SFA 0.0175 ± 0.0056 0.0017 −0.0018 ± 0.0039 0.6429
        VFA/SFA 0.0047 ± 0.0063 0.4591 −0.0013 ± 0.0062 0.8343
rs4846567 LYPLAL1 T/G 0.3 VFA −0.0002 ± 0.0068 0.982 −0.0093 ± 0.0051 0.0702
        SFA 0.0111 ± 0.0047 0.0192 0.0042 ± 0.0033 0.2048
        VFA/SFA −0.0114 ± 0.0053 0.0325 −0.0136 ± 0.0052 0.0091
rs6548238 TMEM18 T/C 0.09 VFA −0.0169 ± 0.0111 0.1295 0.0044 ± 0.0085 0.603
        SFA −0.0174 ± 0.0078 0.0252 −0.0010 ± 0.0054 0.8566
        VFA/SFA 0.0004 ± 0.0088 0.9628 0.0052 ± 0.0086 0.5435
rs713586 RBJ C/T 0.46 VFA 0.0089 ± 0.0062 0.1552 0.0055 ± 0.0047 0.2442
        SFA 0.0104 ± 0.0044 0.0168 0.0078 ± 0.0030 0.01
        VFA/SFA −0.0016 ± 0.0049 0.7375 −0.0024 ± 0.0048 0.618
rs10195252 GRB14-COBLL1 C/T 0.1 VFA 0.0079 ± 0.0104 0.447 −0.0052 ± 0.0079 0.5051
        SFA 0.0162 ± 0.0072 0.025 0.0063 ± 0.0051 0.2169
        VFA/SFA −0.0083 ± 0.0082 0.3079 −0.0115 ± 0.0080 0.1533
rs2535633 ITIH4-AS1 C/G 0.41 VFA 0.0099 ± 0.0064 0.1215 −0.0012 ± 0.0049 0.8127
        SFA 0.0012 ± 0.0045 0.7828 −0.0071 ± 0.0031 0.0225
        VFA/SFA 0.0087 ± 0.0050 0.0844 0.0060 ± 0.0050 0.225
rs7647305 ETV5 T/C 0.06 VFA −0.0280 ± 0.0136 0.0391 −0.0122 ± 0.0103 0.2354
        SFA −0.0152 ± 0.0095 0.1085 −0.0030 ± 0.0066 0.6501
        VFA/SFA −0.0127 ± 0.0107 0.2365 −0.0091 ± 0.0105 0.3849
rs2112347 POC5 T/G 0.41 VFA −0.0079 ± 0.0065 0.2239 −0.0111 ± 0.0049 0.024
        SFA −0.0025 ± 0.0046 0.5787 −0.0050 ± 0.0032 0.1133
        VFA/SFA −0.0055 ± 0.0051 0.2834 −0.0062 ± 0.0050 0.2181
rs9356744 CDKAL1 C/T 0.4 VFA −0.0055 ± 0.0065 0.3962 −0.0106 ± 0.0049 0.0318
        SFA 0.0012 ± 0.0045 0.7863 −0.0025 ± 0.0032 0.4284
        VFA/SFA −0.0068 ± 0.0051 0.1833 −0.0081 ± 0.0050 0.1057
rs206936 NUDT3 A/G 0.48 VFA −0.0076 ± 0.0063 0.2254 −0.0005 ± 0.0048 0.9179
        SFA −0.0121 ± 0.0044 0.0061 −0.0066 ± 0.0031 0.0318
        VFA/SFA 0.0045 ± 0.0050 0.3662 0.0061 ± 0.0049 0.2071
rs671 ALDH2 A/G 0.22 VFA −0.036 ± 0.0075 1.94 × 10−6a −0.0224 ± 0.0057 9.64 × 10−5c
        SFA −0.0131 ± 0.0053 0.0132 −0.0025 ± 0.0037 0.4966
        VFA/SFA −0.0229 ± 0.0059 1.19 × 10−4b −0.0199 ± 0.0058 6.54 × 10−4d
rs9939609 FTO A/T 0.12 VFA 0.0200 ± 0.0098 0.0407 0.0057 ± 0.0074 0.4452
        SFA 0.0131 ± 0.0068 0.0568 0.0021 ± 0.0048 0.6605
        VFA/SFA 0.0072 ± 0.0077 0.3546 0.0037 ± 0.0076 0.6225
rs17782313 MC4R C/T 0.22 VFA 0.0179 ± 0.0076 0.0178 0.0010 ± 0.0058 0.8662
        SFA 0.0116 ± 0.0053 0.0284 −0.0013 ± 0.0037 0.7179
        VFA/SFA 0.0065 ± 0.0060 0.2742 0.0025 ± 0.005874 0.6686
rs29941 KCTD15 C/T 0.24 VFA 0.0069 ± 0.0073 0.3477 −0.0047 ± 0.0056 0.4012
        SFA 0.0134 ± 0.0051 0.0089 0.0046 ± 0.0036 0.1945
        VFA/SFA −0.0067 ± 0.0058 0.2481 −0.0095 ± 0.0057 0.095
rs4823006 ZNRF3 A/G 0.46 VFA −0.0086 ± 0.0064 0.1748 −0.0007 ± 0.0048 0.8879
        SFA −0.0094 ± 0.0044 0.0339 −0.0031 ± 0.0363 0.3114
        VFA/SFA 0.0007 ± 0.0050 0.8899 0.0023 ± 0.0049 0.6346

SNP, single nucleotide polymorphism; Alleles, minor/major alleles; MAF minor allele frequency;SE, standard error; VFA, visceral fat area; SFA, subcutaneous fat area; VFA-SFA, the ratio of visceral fat to subcutaneous fat.

Only SNPs that showed nominal significant associations with traits are shown in Table 3.

P values < 0.05 are shown in bold.

Traits were adjusted for age and sex in the additive genetic model 1 and adjusted for age, sex, and BMI in model 2.

aEmpirical P = 0.0003.

bEmpirical P = 0.0057.

cEmpirical P = 0.0043.

dEmpirical P = 0.0345; Empirical P values were based on 10000 permutations within each trait.