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. 2016 Feb 5;6:20691. doi: 10.1038/srep20691

Table 4. Gender differences in how the variants influence fat distribution.

SNP Gene Alleles MAF Traits Males Females P for interaction
BETA ± SE P BETA ± SE P
rs4846567 LYPLAL1 T/G 0.3 VFA −0.0087 ± 0.0083 0.2964 −0.0100 ± 0.0062 0.1063 0.6223
        SFA −0.0045 ± 0.0045 0.3261 0.0113 ± 0.0046 0.0144 0.0406
        VFA/SFA −0.0043 ± 0.0079 0.5866 −0.0216 ± 0.0069 0.0018 0.0732
rs713586 RBJ C/T 0.46 VFA 0.0068 ± 0.0075 0.3667 0.0064 ± 0.0058 0.2727 0.9455
        SFA 0.0044 ± 0.0041 0.2868 0.0119 ± 0.0044 0.0064 0.2437
        VFA/SFA 0.0081 ± 0.0066 0.2197 0.0039 ± 0.0074 0.5954 0.4853
rs4684854 PPARG G/C 0.08 VFA −0.0040 ± 0.0143 0.7818 0.0246 ± 0.0111 0.0262 0.0812
        SFA 0.0002 ± 0.0078 0.9789 −0.0062 ± 0.0083 0.4533 0.6725
        VFA/SFA −0.0043 ± 0.0137 0.752 0.0314 ± 0.0124 0.0111 0.0437
rs2535633 ITIH4-AS1 C/G 0.41 VFA 0.0002 ± 0.0078 0.9778 −0.0048 ± 0.0059 0.4173 0.2538
        SFA −0.0042 ± 0.0043 0.3218 −0.0108 ± 0.0044 0.0147 0.1128
        VFA/SFA 0.0043 ± 0.0075 0.5608 0.0061 ± 0.0066 0.3535 0.9261
rs10938397 GNPDA2 G/A 0.3 VFA 0.0019 ± 0.0085 0.8279 −0.0028 ± 0.0063 0.6514 0.6623
        SFA 0.0082 ± 0.0046 0.0781 −0.0095 ± 0.0047 0.0433 0.0087
        VFA/SFA −0.0065 ± 0.0081 0.4274 0.0066 ± 0.0070 0.3524 0.22
rs4712652 CASC15 /PRL G/A 0.14 VFA 0.0059 ± 0.0113 0.5975 −0.0180 ± 0.0085 0.0353 0.1367
        SFA −0.0006 ± 0.0061 0.9189 0.0001 ± 0.0064 0.9892 0.8117
        VFA/SFA 0.0066 ± 0.0107 0.5361 −0.0176 ± 0.0095 0.0658 0.114
rs206936 NUDT3 A/G 0.48 VFA −0.0058 ± 0.0076 0.4388 0.0016 ± 0.0059 0.7848 0.385
        SFA −0.0102 ± 0.0041 0.0132 −0.0048 ± 0.0044 0.2826 0.2953
        VFA/SFA 0.0044 ± 0.0072 0.5415 0.0064 ± 0.0066 0.3334 0.8493
rs6905288 VEGFA G/A 0.26 VFA 0.0005 ± 0.0091 0.96 −0.0135 ± 0.0066 0.0395 0.1641
        SFA 0.0043 ± 0.004956 0.3907 −0.0054 ± 0.0049 0.2733 0.1093
        VFA/SFA −0.0039 ± 0.0087 0.6499 −0.0079 ± 0.0073 0.2838 0.7499
rs1055144 NFE2L3 A/G 0.44 VFA 0.0056 ± 0.0075 0.451 0.0002 ± 0.0059 0.9758 0.5147
        SFA −0.0080 ± 0.0041 0.0492 −0.0005 ± 0.0044 0.9014 0.2794
        VFA/SFA 0.0136 ± 0.0071 0.0559 0.0008 ± 0.0065 0.8997 0.191
rs2075064 LHX2 A/G 0.43 VFA −0.0005 ± 0.0076 0.9428 −0.0040 ± 0.0059 0.4964 0.8214
        SFA −0.0086 ± 0.0041 0.0373 0.0025 ± 0.0044 0.569 0.0474
        VFA/SFA 0.0080 ± 0.0072 0.2702 −0.0066 ± 0.0066 0.3183 0.1418
rs4074134 BDNF A/G 0.44 VFA −0.0024 ± 0.0077 0.7533 0.0118 ± 0.0059 0.0462 0.0951
        SFA −0.0020 ± 0.0042 0.6253 0.0074 ± 0.0044 0.0979 0.0703
        VFA/SFA −0.0004 ± 0.0073 0.9601 0.0044 ± 0.0066 0.5033 0.6242
rs3817334 MTCH2 T/C 0.33 VFA −0.0075 ± 0.0083 0.3651 0.0044 ± 0.0063 0.4844 0.3136
        SFA −0.0091 ± 0.0045 0.0427 −0.0039 ± 0.0047 0.4057 0.506
        VFA/SFA 0.0015 ± 0.0079 0.8475 0.0081 ± 0.0070 0.2505 0.5769
rs671 ALDH2 A/G 0.22 VFA −0.0529 ± 0.0093 1.75 × 10−8a 0.0025 ± 0.0069 0.7173 9.88 × 10−8
        SFA −0.0040 ± 0.0051 0.4345 −0.0003 ± 0.0051 0.9544 0.3102
        VFA/SFA −0.049 ± 0.0089 4.43 × 10−8a 0.0027 ± 0.0077 0.7241 4.67 × 10−6
rs9568856 OLFM4 A/G 0.31 VFA 0.0003 ± 0.0083 0.9693 0.0011 ± 0.0065 0.8642 0.9478
        SFA 0.0025 ± 0.0045 0.5873 0.0096 ± 0.0048 0.0468 0.3671
        VFA/SFA −0.0022 ± 0.0079 0.7839 −0.0086 ± 0.0072 0.2326 0.5215
rs10146997 NRXN3 G/A 0.003 VFA −0.0886 ± 0.0879 0.3135 0.0908 ± 0.0497 0.0678 0.0303
        SFA −0.0012 ± 0.0479 0.9797 0.0739 ± 0.0372 0.047 0.1384
        VFA/SFA −0.0853 ± 0.0838 0.3089 0.0169 ± 0.0556 0.7606 0.2434
rs1424233 MAF G/A 0.32 VFA −0.0084 ± 0.0081 0.2981 0.0110 ± 0.0062 0.0785 0.0582
        SFA −0.0015 ± 0.0044 0.7351 −0.0032 ± 0.0047 0.4908 0.7703
        VFA/SFA −0.0068 ± 0.0077 0.3792 0.0140 ± 0.0070 0.0443 0.0443

SNP, single nucleotide polymorphism; Alleles, minor/major alleles; MAF minor allele frequency; SE, standard error; VFA, visceral fat area; SFA, subcutaneous fat area; VFA-SFA, the ratio of visceral fat to subcutaneous fat.

Only SNPs that showed nominal significant associations with traits are shown in Table 4.

P values <0.05 are shown in bold.

Traits were adjusted for age and BMI in the additive genetic model.

aEmpirical P = 1 × 10-4; Empirical P values were based on 10000 permutations within each trait.