Table 1.
The Top 25 Genes Up-Regulated by TGF-β1 and Reversed by PGE2
| Symbol | Description | TGF-β1 ↑ |
PGE2 ↓* |
Fold Change Ratio† | ||
|---|---|---|---|---|---|---|
| Fold Change | P Value | Fold Change | P value | |||
| RTKN2 | Rhotekin 2 | 3.18 | 1.40E-02 | 15.24 | 1.01E-05 | 4.79 |
| ACTG2 | Actin, gamma 2, smooth muscle, enteric | 6.23 | 1.49E-04 | 22.16 | 5.04E-07 | 3.56 |
| C21orf7 | Chromosome 21 open reading frame 7 | 3.48 | 6.08E-06 | 12.04 | 4.02E-09 | 3.46 |
| C1orf198 | Chromosome 1 open reading frame 198 | 2.33 | 4.00E-03 | 7.52 | 1.02E-06 | 3.23 |
| OLR1 | Oxidized low-density lipoprotein (lectin-like) receptor 1 | 2.28 | 2.40E-02 | 6.96 | 2.58E-05 | 3.05 |
| CAMK1D | Calcium/calmodulin-dependent protein kinase ID | 2.45 | 7.16E-06 | 7.21 | 2.54E-08 | 2.95 |
| CBS | Cystathionine-beta-synthase | 2.08 | 2.60E-02 | 5.82 | 2.43E-05 | 2.79 |
| BHLHE41 | Basic helix-loop-helix family, member e41 | 2.00 | 7.00E-03 | 5.58 | 1.84E-06 | 2.79 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 2.97 | 1.09E-04 | 7.94 | 1.19E-07 | 2.68 |
| AFF3 | AF4/FMR2 family, member 3 | 5.28 | 5.17E-08 | 14.03 | 2.20E-10 | 2.66 |
| SLC1A4 | Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 2.95 | 7.76E-04 | 7.06 | 1.87E-06 | 2.39 |
| PRSS35 | Protease, serine, 35 | 2.43 | 2.70E-04 | 5.74 | 2.28E-07 | 2.36 |
| AGT | Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 2.73 | 1.00E-02 | 6.32 | 5.45E-05 | 2.31 |
| ANXA3 | Annexin A3 | 2.00 | 3.70E-04 | 4.50 | 2.02E-08 | 2.25 |
| ASNS | Asparagine synthetase (glutamine-hydrolyzing) | 2.48 | 1.00E-03 | 5.50 | 2.54E-06 | 2.22 |
| UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats | 2.60 | 3.00E-03 | 5.74 | 1.13E-05 | 2.20 |
| CNN1 | Calponin 1, basic, smooth muscle | 8.34 | 4.70E-06 | 18.13 | 9.57E-08 | 2.17 |
| GATA6 | GATA binding protein 6 | 3.53 | 6.52E-06 | 7.36 | 3.63E-08 | 2.08 |
| MTHFD2 | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.32 | 8.32E-06 | 6.73 | 4.49E-08 | 2.03 |
| TUFT1 | Tuftelin 1 | 2.50 | 5.00E-03 | 5.03 | 2.70E-05 | 2.01 |
| NRXN3 | Neurexin 3 | 4.35 | 3.52E-04 | 8.75 | 4.95E-06 | 2.01 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 2.55 | 2.89E-05 | 5.06 | 7.02E-08 | 1.99 |
| NAV3 | Neuron navigator 3 | 3.16 | 1.27E-06 | 6.28 | 6.53E-09 | 1.99 |
| TAGLN | Transgelin | 2.68 | 1.00E-03 | 5.28 | 7.20E-06 | 1.97 |
| PCK2 | Phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.25 | 6.23E-05 | 6.28 | 4.04E-07 | 1.93 |
Definition of abbreviations: PGE2, prostaglandin E2; TGF-β1, transforming growth factor-β1.
*
Fold change by PGE2 relative to TGF-β1 treatment.
†
Genes are ranked by the ratio of the fold change by PGE2/fold change by TGF-β1.