Table 2.
Interleukin-8 Release from LPS-Treated Peripheral Blood Mononuclear Cells from Nonsmokers, Smokers, and Patients with Chronic Obstructive Pulmonary Disease
| Groups | ZT (h) |
|||
|---|---|---|---|---|
| 0 | 6 | 12 | 18 | |
| Nonsmokers | ||||
| Control | 486.3 ± 259.3 | 513.7 ± 113.0 | 774.3 ± 329.7 | 1,301.3 ± 788.8 |
| SRT1720 | 551.5 ± 253.0 | 535.8 ± 199.0 | 531.2 ± 190.3 | 776.4 ± 392.9 |
| LPS | 911.9 ± 498.3 | 658.2 ± 292.3 | 986.7 ± 241.5 | 1,035.6 ± 302.7 |
| LPS+SRT1720 | 538.7 ± 184.0 | 613.8 ± 165.9 | 782.1 ± 230.5 | 735.1 ± 74.8 |
| Smokers | ||||
| Control | 613.7 ± 275.4 | 687.4 ± 182.3 | 571.2 ± 145.0 | 639.6 ± 197.6 |
| SRT1720 | 870.9 ± 190.6 | 656.4 ± 112.0 | 511.9 ± 145.5 | 523.5 ± 66.3 |
| LPS | 1,570.9 ± 389.2* | 865.6 ± 111.0 | 932.8 ± 157.7 | 881.3 ± 191.8 |
| LPS+SRT1720 | 1,291.5 ± 312.7 | 1,226.9 ± 126.9 | 778.3 ± 239.1 | 936.4 ± 249.7 |
| COPD | ||||
| Control | 956.8 ± 168.9 | 534.5 ± 149.9 | 479.9 ± 110.0 | 690.7 ± 220.0 |
| SRT1720 | 803.0 ± 136.7 | 495.8 ± 132.4 | 465.3 ± 120.5 | 423.9 ± 87.7 |
| LPS | 1,115.2 ± 150.5 | 927.1 ± 202.0 | 1,070.8 ± 236.0* | 940.6 ± 166.1 |
| LPS+SRT1720 | 1,064.8 ± 155.8 | 890.6 ± 173.5 | 900.1 ± 162.8 | 824.3 ± 146.9 |
Definition of abbreviations: COPD, chronic obstructive pulmonary disease; ZT, Zeitgeber time.
Mean values (pg/ml) ± SEM of IL-8 are shown (n = 6–9/group).
*
P < 0.05 versus corresponding control.