Figure 3.

(A and B) Effect of agonist application on ASMC Ca²⁺ dynamics with different levels of pre-existing luminal RyR sensitization (r_s; increasing from top to bottom—red to blue to green), in the absence of cytosolic RyR sensitization (r_c = 0). (A) Low [IP₃] (p = 0.5), and (B) high [IP₃] (p = 1.5), applied at t of 200 seconds (p = IP₃ concentration). (C and D) Long-term mean [Ca²⁺]_i (black) and Ca²⁺ oscillation frequency (red) as a function of luminal RyR sensitization for the two agonist levels in A and B.